Fast Five Quiz: Treatment of Hereditary (Familial) Amyloid Transthyretin-Related (hATTR) Amyloidosis

Jefferson R. Roberts, MD; Victoria M.F. Mank, MD


May 24, 2021

Recommended clinical criteria for orthotopic liver transplantation in individuals with hATTR amyloidosis include:

  • Polyneuropathy restricted to lower extremities or autonomic neuropathy alone

  • Younger than 60 years of age

  • Disease duration < 5 years

  • No significant cardiac or renal dysfunction

Orthotopic liver transplantation is not effective in the nonneuropathic forms of hATTR amyloidosis, which include cardiac amyloidosis, leptomeningeal amyloidosis, and familial oculoleptomeningeal amyloidosis. In other patients, liver transplantation appears to halt progression of sensory, motor, and autonomic neuropathy. Performing the liver transplantation as early in the disease course as possible, before significant neurologic disability has been incurred, is preferable.

Learn more about liver transplantation in patients with hATTR amyloidosis.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.