Recommended clinical criteria for orthotopic liver transplantation in individuals with hATTR amyloidosis include:
Polyneuropathy restricted to lower extremities or autonomic neuropathy alone
Younger than 60 years of age
Disease duration < 5 years
No significant cardiac or renal dysfunction
Orthotopic liver transplantation is not effective in the nonneuropathic forms of hATTR amyloidosis, which include cardiac amyloidosis, leptomeningeal amyloidosis, and familial oculoleptomeningeal amyloidosis. In other patients, liver transplantation appears to halt progression of sensory, motor, and autonomic neuropathy. Performing the liver transplantation as early in the disease course as possible, before significant neurologic disability has been incurred, is preferable.
Learn more about liver transplantation in patients with hATTR amyloidosis.
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Cite this: Jefferson R. Roberts, Victoria M.F. Mank. Fast Five Quiz: Treatment of Hereditary (Familial) Amyloid Transthyretin-Related (hATTR) Amyloidosis - Medscape - May 24, 2021.