Intraoperative norepinephrine and ketamine should be used cautiously and is contraindicated in situations where increased blood pressure would be hazardous (eg, hypertension, stroke, head trauma, intracranial bleeding). The most common adverse effects associated with IV ketamine (Ketalar) include:
Increased cardiac output
Increased intracranial pressure
Read more on ketamine use.
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Cite this: Mary L Windle. Fast Five Quiz: Ketamine - Medscape - May 23, 2019.