A 20-Year-Old Woman With Nail Abnormalities and Vomiting

Sumaira Nabi, MBBS; Shahzad Ahmed, MBBS; Mazhar Badshah, MBBS

Disclosures

June 06, 2019

Management is directed at manifestations. Treatment of epilepsy in patients with TS is difficult and often requires polytherapy. Depending on the type of seizures, appropriate and adequate antiepileptics should be prescribed. Nearly 63% cases of epilepsy in TS are medically refractory.[14] A ketogenic diet or vagus nerve stimulation are options for these patients.[15]

Treatment options for brain tumors associated with TS include surgical resection or medical therapy with mammalian target of rapamycin (mTOR) inhibitors, such as everolimus.[16] If present, renal, pulmonary, and cardiac disease require referral and management by relevant specialists. The prognosis varies and depends on the number and severity of organ systems involved. It is a progressive disorder, and complications lead to morbidity and mortality. Status epilepticus, SEGA, and renal disease are the most common causes of death.

In this case, the patient's antiepileptic medication was adjusted, and she was referred to a urology specialist, who is helping to plan a right-sided nephrectomy.

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