Clinical manifestations of PAH may include the following:
History of heart murmur
Deep venous thrombosis or pulmonary embolism
Arthritis or arthralgias
Heavy alcohol consumption
Family history of pulmonary hypertension
Drug use, in particularly diet drugs and illicit drugs
Patients with PAH may also have nonspecific symptoms secondary to pulmonary hypertension. These may include the following:
Dyspnea on exertion
Syncope with exertion
Right upper quadrant pain
Less common symptoms include the following:
Hoarseness (resulting from compression of the recurrent laryngeal nerve by the distended pulmonary artery)
The intensity of the pulmonic component of the P2 may be increased, and the P2 may demonstrate fixed or paradoxical splitting. A systolic ejection murmur may be heard over the left sternal border. The murmur may be augmented by inspiration. A right ventricular heave may be palpated.
Although PAH has been associated with thyroid dysfunction, the most common association is with hyperthyroidism.
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Cite this: Zab Mosenifar. Fast Five Quiz: Pulmonary Arterial Hypertension - Medscape - Jun 14, 2019.