According to AHRQ guidelines, nortriptyline and bupropion SR are effective medications in patients with a history of depression who are attempting to quit smoking.
Bupropion SR, nicotine gum, nicotine inhaler, nicotine nasal spray, and the nicotine patch are all considered first-line pharmacotherapies. However, because of insufficient data, the choice of treatment must be guided by individualized factors. These include patient preference, previous patient experience, contraindications, and clinician familiarity with the medication. Clonidine and nortriptyline are second-line pharmacotherapies.
Bupropion SR and particularly nicotine gum have been shown to delay weight gain in patients attempting smoking cessation. However, they do not prevent weight gain entirely.
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Cite this: George D. Harris. Fast Five Quiz: Modifiable Cancer Risk Factors - Medscape - Jul 26, 2019.