Initial HCV testing: HCV antibody test is recommended. If the result is positive, confirm current infection with a sensitive HCV RNA test.
Negative HCV antibody test but clinical suspicion of liver disease: Test for HCV RNA or perform follow-up testing for HCV antibody if HCV exposure occurred within the past 6 months; consider testing for HCV RNA in immunocompromised individuals.
Reinfection after previous spontaneous or treatment-related viral clearance: Obtain initial HCV RNA testing (because an HCV antibody test result is expected to be positive).
Before initiation of antiviral therapy: Obtain quantitative HCV RNA testing to document baseline viral load.
Selection of most appropriate antiviral regimen: Use HCV genotype testing for guidance.
Positive HCV antibody test with negative HCV RNA by PCR: Inform patients they do not have evidence of current (active) HCV infection.
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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: B.S. Anand. Fast Five Quiz: Liver Disease - Medscape - Aug 16, 2019.