Fast Five Quiz: Neuropathic, Nociceptive, and Mixed Pain

Shaheen E. Lakhan, MD, PhD, MS, MEd

Disclosures

September 10, 2019

Nociceptive pain, such as gout, is associated with the activation of nociceptors—sometimes in the presence of active inflammation—whereas mixed pain is a combination of nociceptive pain, neuropathic pain, and nociplastic pain, which the IASP has defined as arising from "altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain."

Examples of mixed pain include cancer pain, sciatica, and osteoarthritis.

Learn more about mixed pain etiologies.

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