Fast Five Quiz: Secondary Progressive Multiple Sclerosis

Krupa Pandey, MD


February 16, 2021

The discovery of a gut-brain axis with bacteria capable of prompting cerebral inflammation has been proposed as a novel theory of disease development. Studies, including a recent investigation by Kadowaki and colleagues, have demonstrated the role of the gut-brain axis in patients with SPMS. Growing evidence has shown the alteration of a subgroup of T cells from regulatory cells to proinflammatory cells that cause an autoimmune attack on the brain. Links to gut-brain axis dysfunction are also present in patients with RRMS.

New information has revealed that the CCR9+ CD4+ T cells present in patients with RRMS are decreased in patients with SPMS and become proinflammatory.

In patients with SPMS, there is not an increase but a decrease in T-cell proliferation, namely the CCR9+ CD4+ T cells.

Learn more about the role of the gut-brain axis in SPMS.


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