In patients with SPMS, inflammatory cells accumulate within the arachnoid membrane and the pia mater. The subarachnoid space and associated perivascular spaces between the membranes of the meninges serve as entry points into the brain parenchyma for lymphocytes, monocytes, and macrophages. These spaces are also the main gateway for inflammatory and cytotoxic molecule diffusion, moving from the cerebrospinal fluid into the brain tissue.
In patients with RRMS, inflammatory cells are typically found within the demyelinating lesions, the white matter of the brain, and within axons in the spinal cord.
Learn more about the pathophysiology of SPMS.
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Cite this: Krupa Pandey, Christopher Luzzio. Fast Five Quiz: Secondary Progressive Multiple Sclerosis - Medscape - Oct 09, 2023.