The meninges play an important role in regulating the entry of immune cells into the CNS. In patients with SPMS, inflammatory cells accumulate within the arachnoid membrane and the pia mater. In a recent review, Lasserman suggests the occurrence of several physiologic changes beyond that of simple progression or accumulation of disability from RRMS to SPMS.
In patients with RRMS, inflammatory cells are found within the demyelinating lesions, the white matter of the brain, and within axons in the spinal cord.
Learn more about the pathophysiology of MS.
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Cite this: Krupa Pandey. Fast Five Quiz: Secondary Progressive Multiple Sclerosis - Medscape - Feb 16, 2021.