Physical Examination and Workup
On examination, the patient's vital signs were within normal limits. A physical examination revealed normal abdominal findings. His knees had full range of motion bilaterally and were without crepitus or effusion. Lower-extremity examination revealed scattered erythematous, hyperpigmented papules on both legs. Otherwise, physical examination findings were unremarkable.
Repeat laboratory assessment was notable for the following:
Creatinine level: 2.1 mg/dL (posttransplant creatinine baseline level, 1.36 mg/dL)
Blood urea nitrogen level: 22 mg/dL (typical reference range, 7-20 mg/dL)
Total protein: 7 g/dL (reference range, 6-8.3 g/dL)
Albumin level: 3.2 g/dL (reference range, 3.4-5 g/dL)
Dipstick urinalysis with microscopic examination revealed > 100 red blood cells per high-power field and 1+ protein.
The following day, the patient's tacrolimus trough level was supratherapeutic, at 11 ng/mL (reference range, 5-10 ng/mL). The tacrolimus dose was adjusted, and the patient was instructed to follow up at a clinic in 1 week. At that visit, the patient's creatinine level had increased to 2.8 mg/dL and his tacrolimus level was 9 ng/mL. In addition, his aspartate aminotransferase and alanine aminotransferase levels were now elevated, at 68 U/L (reference range, 5-34 U/L) and 66 U/L (reference range, 0-55 U/L), respectively.
Over the course of another week, while workup for the patient's acute kidney injury and HCV was pursued, his creatinine level continued to rise (3.1 mg/dL). Additional laboratory investigation revealed the following:
BK virus: negative
Tacrolimus level: 9 ng/mL
HCV RNA: 35,591,559 copies/mL
HCV genotype: 1a
C4 level: 6 mg/dL (reference range, 15-57 mg/dL)
C3 level: 86 mg/dL (reference range, 82-193 mg/dL)
Antinuclear antibody (Ab): positive
Anti-dsDNA Ab: negative
Erythrocyte sedimentation rate: 47 mm/h (reference range, 0-30 mm/h)
C-reactive protein level: 27 mg/dL (reference range, < 0.5 mg/dL)
Rheumatoid factor : 63 IU/mL (reference range, < 14 IU/mL)
Anti-RNP Ab: < 10 U (reference range, < 10 U)
Antihistone Ab: negative
Anti-Smith Ab: negative
Renal biopsy of the graft kidney is shown in Figures 2 and 3.
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Cite this: F. Gerald Wade, Elie Ghoulam, Thomas Fay, et. al. A 58-Year-Old Man With a Rash and Elevated Creatinine Levels - Medscape - Oct 02, 2019.