Fast Five Quiz: Chronic Spontaneous Urticaria

Figure 1. Mast cell releasing histamine

Derangement of mast cell activation and degranulation plays a key role in the pathophysiology of CSU. When mast cells are stimulated, histamine and prostaglandin mediators and cytokines are released, along with other attractants that assist in forming wheals with vasodilation and erythema (hives). This complex interaction leads to a lymphocyte- and granulocyte-mediated hypersensitivity skin reaction.

Histamine release in the lungs and depolarization of neurons are not central to the pathophysiology of CSU. Although lower serum B₁₂ levels have been noted in patients with CSU, vitamin B₁₂ deficiency is neither central to nor associated with the pathophysiology of CSU.

Learn more about the pathophysiology of CSU.

Medscape © 2020 WebMD, LLC

Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: William D. James. Fast Five Quiz: Chronic Spontaneous Urticaria - Medscape - Jun 15, 2020.