Fast Five Quiz: Advanced and Metastatic Prostate Cancer Presentation and Diagnosis

Daniel S. Schwartz, MD, MBA


June 27, 2022

Figure 1. Confocal light micrograph of metastasizing prostate cancer cells

Lower extremity pain and edema may occur in the setting of metastatic disease as a result of obstruction of venous and lymphatic tributaries by nodal metastasis. Other symptoms of advanced disease include anemia, weight loss and loss of appetite, and bone pain with or without pathologic fracture.

Prior to the advent of PSA testing, men with prostate cancer often had local symptoms that included hematuria and urinary retention. Today, the most common local symptoms include urinary frequency (38%), decreased urine stream (23%), and urinary urgency (10%), according to Cheuck and colleagues.

The symptoms of uremia can occur in men with advanced or metastatic prostate cancer as the result of ureteral obstruction caused by local prostate growth or retroperitoneal adenopathy secondary to nodal metastasis.

Learn more about the signs and symptoms of advanced and metastatic prostate cancer.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.