In patients with advanced or metastatic prostate cancer, physical examination findings may include adenopathy; other findings in patients with advanced disease may include cancer cachexia, lower extremity lymphedema or deep venous thrombosis, bony tenderness, and over-distended bladder due to outlet obstruction.
Low-grade prostate cancers can be biologically active. In high-grade prostate cancer, the percentage of Gleason grades 4 and 5 disease present is associated with adverse pathologic findings and disease progression.
Obliteration of the lateral sulcus found during rectal examination frequently indicates locally advanced disease, as does seminal vesical involvement.
Learn more about the presentation of advanced and metastatic prostate cancer.
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Cite this: Daniel S. Schwartz. Fast Five Quiz: Advanced and Metastatic Prostate Cancer Presentation and Diagnosis - Medscape - Jun 27, 2022.