Fast Five Quiz: Metastatic Hormone-Sensitive Prostate Cancer Treatment

Bradley Schwartz, DO

Disclosures

December 03, 2020

Figure 1. PET scans of 63-year-old man with metastatic prostate cancer.

Recently published data from a correlative study of the phase 3 E3805 CHAARTED clinical trial showed that patients with mHSPC with a luminal B tumor had better outcomes when chemotherapy was added to ADT compared with ADT alone. Specifically, patients with luminal B subtype experienced shorter overall survival compared with those with a basal subtype when treated with ADT alone. The addition of chemotherapy significantly improved overall survival among the luminal B tumor subgroup, but overall survival among patients with a basal tumor was not improved.

Few biomarkers have been identified in mHSPC; however, a 2019 review of treatment options for patients with mHSPC notes that several aberrations found in mCRPC are found in mHSPC at a similar rate of frequency. For example, the prevalence of alterations in PTEN, TP53, FOXA1, PIK3A, APC, and BRCA2 appears comparable between patients with de novo mHSPC and those with mCRPC. Some of these mutations have been associated with responses to specific treatments. For instance, SPOP mutations may predict response to abiraterone acetate. Similarly, homologous recombination repair may be a biomarker of response to both platinum-based chemotherapies and PARP inhibitors.

Learn more about individualizing treatment selection for patients with mHSPC.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....