Fast Five Quiz: Metastatic Hormone-Sensitive Prostate Cancer Treatment

Bradley Schwartz, DO


December 03, 2020

Febrile neutropenia has been reported in 7% of patients receiving docetaxel chemotherapy plus ADT for mHSPC.

There is a high risk for myelosuppression with docetaxel. Therefore, it may be advisable to avoid docetaxel in patients at high risk for this complication.

Hypertension has been among the adverse effects observed with the anti-androgen therapies abiraterone and enzalutamide. A recent meta-analysis showed a moderate risk for hypertension among patients receiving abiraterone. Another meta-analysis showed an increased risk for hypertension with enzalutamide.

Apalutamide and enzalutamide may confer a small risk for seizures; however, no increase in the incidence of seizures has been observed in patients treated with enzalutamide who had a history of seizure or other risk factors in the UPWARD study.

Listen to an expert discuss the management of patients with mHSPC.


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