Individual gout flares are often triggered by acute increases or decreases in urate levels that may lead to the production, exposure, or shedding of crystals. Many factors can result in urate level changes, including acute alcohol ingestion, acute overindulgence in foods high in purines, rapid weight loss, dehydration, or trauma.
Similarly, flares can be precipitated by additions of or changes in dosage of medications that raise or lower uric acid levels. Medications that increase uric acid levels via effects on renal tubular transport include:
Loop and thiazide diuretics (eg, hydrochlorothiazide)
Agents that lower levels of uric acid include:
Xanthine oxidase inhibitors (eg, allopurinol, febuxostat)
Uricosurics (eg, probenecid)
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Cite this: Herbert S. Diamond. Fast Five Quiz: Gout and Pseudogout - Medscape - Dec 04, 2019.