Fast Five Quiz: Chronic Lymphocytic Leukemia (CLL) Presentation and Diagnosis

Karl J. D'Silva, MD


March 08, 2022

Figure 1. Blood smear showing chronic lymphocytic leukemia

CLL is diagnosed when there is evidence of the disease in both the blood and bone marrow. Unlike small lymphocytic lymphoma, which is another manifestation of the same disease, CLL is diagnosed when > 5000 monoclonal lymphocytes/µL are present for longer than 3 months. The bone marrow is either normocellular or hypercellular, with > 30% monoclonal lymphocytes.

Learn more about diagnostic criteria of CLL.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.