Fast Five Quiz: Aspirin Use

Mary L. Windle, PharmD


January 03, 2020

According to 2019 guidelines from the ACC/AHA, aspirin is well established for secondary prevention of ASCVD and is widely recommended. However, aspirin should not be used in the routine primary prevention of ASCVD. In particular, aspirin should be avoided in patients with any of the following:

  • History of gastrointestinal bleeding or peptic ulcer disease

  • Bleeding from other sites

  • Age > 70 years

  • Thrombocytopenia

  • Coagulopathy

  • Chronic kidney disease

  • Concurrent use of nonsteroidal anti-inflammatory drugs, steroids, and anticoagulants

The guidelines recommend the following:

  • Low-dose aspirin may be considered for primary prevention of ASCVD in adults at higher risk who are aged 40-70 years and who are not at increased bleeding risk.

  • Low-dose aspirin should not be routinely administered for primary prevention of ASCVD in adults aged > 70 years.

  • Low-dose aspirin should not be administered for primary prevention among adults of any age who have an increased bleeding risk.

 Read more about ASCVD prevention.


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