The two risk factors most consistently and strongly associated with AD are a family history of atopy and mutations in FLG, according to the AAD. Profilaggrin is degraded to FLG monomers, which are key to epidermal differentiation, natural skin hydration, and skin barrier formation. FLG mutations are strongly associated with early-onset AD and airway disease. The inflammatory response might be triggered by the release of epithelial cell-derived cytokines.
Although elevated total and/or allergen-specific serum IgE level is a common associated feature among patients with AD, it is not present in about 20% of affected individuals.
Learn more about etiology and pathophysiology of AD.
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Cite this: Richard P. Vinson, William James. Fast Five Quiz: Atopic Dermatitis - Medscape - Feb 09, 2023.