Fast Five Quiz: Atopic Dermatitis

Richard P. Vinson, MD


February 11, 2020

The two risk factors most consistently and strongly associated with AD are a family history of atopy and mutations in FLG. Profilaggrin is degraded to FLG monomers, which are key to epidermal differentiation, natural skin hydration, and skin barrier formation. FLG mutations are associated with early-onset AD and airway disease. The inflammatory response might be triggered by the release of epithelial cell-derived cytokines.

Although obesity and poor economic status are often present in patients with AD, these factors have not been consistently linked to AD.

Scabies infestations are not linked to AD but may be mistaken clinically for AD.

Cradle cap is a common form of SD that occurs on the scalp of infants. As previously noted, SD may have a similar clinical presentation to AD and should be excluded.

Learn more about etiology and physiology of AD.


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