Fast Five Quiz: Nasal Polyps Nonsurgical Management

Arlen D. Meyers, MD, MBA


December 08, 2020

Topical nasal corticosteroids provoke a nonspecific anti-inflammatory response that may reduce the size of polyps and inhibit regrowth. As a class, corticosteroids are the only medications that have been shown to be effective for shrinking polyps. However, their effects tend to be short-lasting (weeks to months). A recent study found that a short course of combination oral corticosteroid taper and nasal corticosteroids may be an effective treatment option for patients with severe chronic rhinosinusitis with nasal polyps.

Monoclonal antibodies may be an effective option for the treatment of nasal polyps. In several phase 3 clinical trials, adding a monoclonal antibody to standard-of-care intranasal corticosteroid therapy resulted in significant improvement in nasal congestion/obstruction, the nasal polyp score, sinus opacification, and sense of smell.

Emerging data suggest that anti-IL-5 therapy may improve nasal polyp score in some patients.

Learn more about the nonsurgical treatment of nasal polyps.


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