According to the GINA report, a sputum eosinophil count ≥ 2% is one of several indicators that a patient who is taking high-dose ICS or daily OCS may have type 2 inflammation. The other signs of possible type 2 inflammation include:
Blood eosinophil count ≥ 150/μL
Fractional exhaled nitric oxide (FeNO) level ≥ 25 parts per billion
Asthma that is clinically allergen driven
Patients requiring maintenance OCS therapy (although biomarkers of type 2 inflammation such as blood eosinophil count, sputum eosinophil count, and FeNO level are often suppressed by OCS)
For more on the GINA 2019 update on severe asthma, refer to Part E of the report, beginning on page 84.
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Cite this: Zab Mosenifar. Fast Five Quiz: Severe Asthma - Medscape - Mar 18, 2020.
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