Fast Five Quiz: Plaque Psoriasis

William James, MD


June 09, 2021

Histologic findings in patients with plaque psoriasis include abnormal keratinocyte differentiation throughout the psoriatic plaques, which is manifested by loss of the granular layer. In addition, the stratum corneum is also thickened.

The diagnosis of plaque psoriasis is almost always made based on clinical findings. Skin biopsy can confirm a diagnosis of plaque psoriasis; however, biopsies are typically reserved for the evaluation of atypical cases or to rule out other conditions when there is diagnostic uncertainty. Similarly, laboratory investigations are rarely indicated. Patients with severe disease may have mild hyperuricemia and low folate levels, which is believed to result from enhanced epidermopoiesis.

Signs of inflammation can be seen throughout the dermis in persons with plaque psoriasis, including marked hypervascularity and an increase in the size of the dermal papillae.

Learn more about the signs and symptoms of plaque psoriasis.


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