Fast Five Quiz: Chronic Lymphocytic Leukemia Differential Diagnosis

Karl J. D'Silva, MD

Disclosures

March 09, 2020

CLL and SLL are different manifestations of the same disease; SLL is diagnosed when the disease is mainly nodal, and CLL is diagnosed when the disease is seen in the blood and bone marrow. Patients with < 5000 B lymphocytes/µL and lymphadenopathy but no cytopenias are more likely to have SLL rather than CLL, although lymph node biopsy should be performed to confirm this diagnosis.

Learn more about the workup of patients suspected of having CLL.

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