Fast Five Quiz: HIV Antiretroviral Therapy

Jason F. Okulicz, MD


September 11, 2020

Figure 1. Electron Microscope Image of HIV

Because of the highly mutable nature of HIV, antiretroviral agents are designed to attack the virus at various stages of its replication cycle. Although HIV targets CD4 T cells, as well as macrophage and dendritic cells, treatment agents were developed on the basis of the replication cycle of HIV itself. Treatment agents exploit all stages of viral replication, including binding and fusion; conversion and integration; replication; and assembly, budding, and maturation. Likewise, these agents exhibit mechanisms of action that are both intracellular, such as integrase strand-transfer inhibitors, and extracellular, such as fusion inhibitors.

Learn more background information about ART.


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