Clubbing can be idiopathic or secondary to many underlying pathologies in various organ systems. Causes of idiopathic or primary clubbing include pachydermoperiostosis, familial clubbing, and hypertrophic osteoarthropathy. Causes of secondary clubbing include:
Pulmonary disease: Lung cancer, cystic fibrosis, interstitial lung disease, idiopathic pulmonary fibrosis, sarcoidosis, lipoid pneumonia, empyema, pleural mesothelioma, pulmonary artery sarcoma, lung hydatid cysts, and pulmonary metastases
Cardiac disease: Cyanotic congenital heart disease, other causes of right-to-left shunting, and bacterial endocarditis
Gastrointestinal disease: Ulcerative colitis, Crohn disease, primary biliary cirrhosis, cirrhosis of the liver, hepatopulmonary syndrome, leiomyoma of the esophagus, achalasia, and peptic ulceration of the esophagus
Skin disease: Pachydermoperiostosis, Bureau-Barrière-Thomas syndrome, Fischer syndrome, palmoplantar keratoderma, and Volavsek syndrome
Malignancies: Thyroid cancer, thymus cancer, Hodgkin disease, and disseminated chronic myeloid leukemia
Miscellaneous conditions: Acromegaly, thyroid acropachy, pregnancy, an unusual complication of severe secondary hyperparathyroidism, sickle cell disease, and hypoxemia
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Cite this: William James. Fast Five Quiz: Fingernail and Toenail Conditions - Medscape - Feb 07, 2020.
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