Fast Five Quiz: Sickle Cell Disease Presentation and Diagnosis

Sophie M. Lanzkron, MD, MHS


August 17, 2023

Each year, as many as 312,000 individuals worldwide are diagnosed with sickle cell disease (SCD). SCD is most common among patients whose ancestors came from sub-Saharan Africa. SCD is a life-threatening hematologic disorder in which there is a disruption of blood flow in small vessels; this vaso-occlusion leads to distal tissue ischemia and inflammation. Repeated episodes of sickling and ongoing hemolytic anemia, even when subclinical, culminate in parenchymal injury and chronic organ damage. Although the disease course is highly variable, significant morbidity and early mortality often ensue. Early diagnosis is key to improving survival.

How much do you know about the presentation and diagnosis of SCD? Test your knowledge with this quick quiz.


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