Creatinine and uric acid are typically hypersecreted in SCD nephropathy. Proximal tubular function is supranormal, as evidenced by an increased reabsorption of phosphorus and β-microglobulins, as well as the increased secretion of uric acid and creatinine.
To determine the need for interventions in sickle cell nephropathy, accurate estimation of renal function is essential. Unfortunately, there is no tool that provides an accurate measure of estimated glomerular filtration rate in patients with SCD.
Learn more about the renal manifestations of SCD.
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Cite this: Sophie M. Lanzkron. Fast Five Quiz: Sickle Cell Disease Presentation and Diagnosis - Medscape - Aug 17, 2023.