Fast Five Quiz: Idiopathic Pulmonary Fibrosis Imaging

Ani Kapoor, MD; Zab Mosenifar, MD


June 21, 2022

Chest HRCT plays a key role in the initial assessment of suspected IPF and has a significant influence on subsequent management decisions. Inflammation is commonly absent or mild in patients with IPF; when present, it consists of an irregular interstitial infiltrate of lymphocytes and plasma cells associated with the hyperplasia of type 2 pneumocytes and the bronchiolar epithelium, per Balestro and colleagues.

Fibrotic areas consist primarily of dense collagen; however, fibroblast foci (the diffuse convex subepithelial foci of proliferating fibroblasts and myofibroblasts) are typical findings in patients with IPF.

Surgical lung biopsy is indicated for patients whose imaging findings are not definitive for UIP, which is the hallmark pattern of IPF. Findings of probable UIP or those that are indeterminate for UIP or alternative diagnosis may warrant a surgical lung biopsy.

Learn more about the workup of patients with suspected IPF.


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