Fast Five Quiz: Idiopathic Pulmonary Fibrosis Imaging

Ani Kapoor, MD; Zab Mosenifar, MD


February 17, 2023

Chest HRCT plays a key role in the initial assessment of suspected IPF and has a significant influence on subsequent management decisions. Inflammation is commonly absent or mild on HRCT in patients with IPF. When present, it typically consists of an irregular interstitial infiltrate of lymphocytes and plasma cells.

According to the ATS/ERS/JRS/ALAT Clinical Practice Guidelines: Diagnosis of Idiopathic Pulmonary Fibrosis, some radiologic features may be more consistent with a non-IPF diagnosis due to their closer association with other ILDs. These features include predominant ground-glass opacities, nodules, consolidation, and subpleural sparing or upper- or middle-lung predominant fibrosis. In addition, mosaic attenuation on HRCT may be suggestive of an alternative diagnosis, particularly fibrotic hypersensitivity pneumonitis.

Learn more about the workup of patients with suspected IPF.


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