Fast Five Quiz: Idiopathic Pulmonary Fibrosis Comorbidities and Complications

Ani Kapoor, MD


July 13, 2020

Studies have suggested that nocturnal hypoxemia is common among patients with IPF. Patients with IPF with the lowest awake oxygen saturation have been shown to have the greatest sleep-related desaturation, particularly during rapid eye movement sleep, which subsequently has a negative effect on quality of life and daytime functioning. The use of overnight oxygen supplementation may be a potential palliative treatment.

Sleep-related disorders have increasingly been shown to be important comorbidities in patients with IPF. Significant impairments such as alterations in sleep architecture, changes in sleep breathing pattern, and, as noted previously, decreases in oxygen saturation have been found in patients with IPF. Evidence also indicates an increased prevalence of obstructive sleep apnea (OSA) in patients with IPF.

In recent years, more research has been conducted related to sleep disturbances in patients with IPF and the possible role of these disturbances in sleep and quality of life, disease progression, and disease outcome. Some of these recent studies provide evidence that shows sleep-related desaturation in patients with IPF may play a role in the development of pulmonary vascular disease and may be a risk factor for increased mortality.

Learn more about comorbidities in patients with IPF.


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