According to the Centers for Disease Control and Prevention (CDC), culture for M genitalium can take up to 6 months, and only a few laboratories in the world are able to recover clinical isolates. Therefore, culture is not useful for diagnosis and NAAT is the preferred method for M genitalium detection.
In the United States, a diagnostic test for M genitalium was approved by the FDA in 2019.
The British Association for Sexual Health and HIV (BASHH) guidelines recommend vaginal swabs as the specimen of choice in cisgender women, and first-void urine as the specimen of choice in cisgender men. For all patients with M genitalium-positive specimens, testing for macrolide resistance is recommended whenever possible.
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Cite this: Ken B. Waites. Fast Five Quiz: Mycoplasma genitalium Presentation and Diagnosis - Medscape - Apr 09, 2020.