Fast Five Quiz: Neuropathic Pain Management

Dianna Quan, MD


March 27, 2020

Figure 1. Illustration, Neural Pain Pathway

There is clinical evidence supporting the use of SNRIs for the treatment of depression with comorbid pain syndromes.

TCAs have a slow onset of action and require several weeks to achieve the full effects of the drug.

Antiseizure drugs (eg, carbamazepine) should be used with caution in patients with hyponatremia.

SSRIs can be used to treat the associated depression and insomnia that is common with neuropathic pain, but they are not very effective at managing the pain. SNRIs are more effective at treating neuropathic pain than SSRIs because higher selectivity for serotonin is associated with weaker analgesic effect.

Learn more about the use of antidepressants for neuropathic pain.


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