Fast Five Quiz: Severe Acute Respiratory Syndrome (SARS)

Michael Stuart Bronze, MD

Disclosures

May 04, 2020

Data from the 2002-2003 outbreak indicate that SARS may be associated with these laboratory findings:

  • Modest lymphopenia, leukopenia, and thrombocytopenia: Case series have shown white blood cell counts less than 3.5 x 109/L and lymphocyte counts less than 1 x 109/L

  • Mild hyponatremia and hypokalemia

  • Elevated levels of lactate dehydrogenase, ALT, and hepatic transaminase

  • Elevated creatine kinase level

In patients with COVID-19, these laboratory findings have been associated with increased risk of acute respiratory distress syndrome and death:

  • Neutrophilia

  • Lymphocytopenia

  • Elevated end-organ–related indices (eg, levels of aspartate aminotransferase, lactate dehydrogenase, urea)

  • Elevated inflammation-related indices (levels of high-sensitivity C-reactive protein and serum ferritin)

  • Elevated coagulation function-related indicators (prothrombin time and D-dimer level)

Read more about the workup of SARS.

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