Severe psoriasis can develop in individuals with uncontrolled HIV infection. According to updated guidelines from the British Association of Dermatologists, HIV viral load must be suppressed on antiretroviral therapy before biologic therapy can be initiated for the treatment of plaque psoriasis in patients with HIV infection.
For patients with HIV infection, phototherapy in conjunction with antiretrovirals is a recommended option; other options include a retinoid agent or topical therapy.
In general, patients with preexisting primary or secondary immunodeficiency should only receive immunosuppressive agents or biologic agents in the setting of severe or recalcitrant psoriasis. In such cases, guidelines recommend consultation with the patient's infectious disease specialist.
Learn more about the management of plaque psoriasis in various patient population.
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Cite this: Chris G. Adigun, William James. Fast Five Quiz: Systemic Treatments for Plaque Psoriasis - Medscape - Dec 21, 2021.