Fast Five Quiz: Huntington Disease

Shaheen E. Lakhan, MD, PhD, MS, MEd


May 27, 2020

The initial stages of Huntington disease are often characterized by deficits in short-term memory. This is frequently followed by motor dysfunction and a variety of cognitive changes, including diminished verbal fluency and problems with attention, executive function, visuospatial processing, and abstract reasoning.

As the disease progresses, chorea coexists with and is then gradually replaced by dystonia and parkinsonian features, including bradykinesia, rigidity, and postural instability.

Akinetic-rigid syndrome occurs in advanced disease with minimal or no chorea.

Although the dementia syndrome associated with Huntington disease includes early-onset behavioral changes such as irritability, untidiness, and loss of interest, the slowing of cognition and impairment of intellectual function, along with memory disturbances, are seen as the disease progresses.

Learn more about the clinical presentation of Huntington disease.


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