Fast Five Quiz: Huntington Disease

Shaheen E. Lakhan, MD, PhD, MS, MEd


May 27, 2020

While there is no cure for Huntington disease, for those patients experiencing symptoms, various medications can improve the quality of life and prevent complications. Treatments for Huntington disease can be divided into drugs to treat the movement disorder and drugs to treat psychiatric or behavioral problems.

Benzodiazepines should be considered in patients with chorea that is severe enough to interfere with function. Other treatment options for chorea include valproic acid, dopamine-depleting agents (eg, reserpine, tetrabenazine deutetrabenazine), and neuroleptics.

Neuroleptics may worsen other features of the disease, such as bradykinesia and rigidity, leading to further functional decline. Patients with predominant features of bradykinesia and rigidity may benefit from treatment with levodopa or dopamine agonists.

Ablative surgical procedures and fetal cell transplantation have been attempted in Huntington disease patients, but there are not enough data to support this type of treatment and it is still considered experimental.

Learn more about the treatment of Huntington disease.


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