Fast Five Quiz: Myelodysplastic Syndrome Management

Emmanuel C. Besa, MD


May 12, 2021

Patients with congestive heart failure and MDS may not tolerate MDS-associated anemia or transfusion-induced blood volume increases as well as other patients. The use of packed red blood cells along with diuretic agents can be helpful to reduce the complication risk in patients with MDS and congestive heart failure.

Although no formal recommendations exist for supportive care measures in MDS, prophylactic antimicrobial therapy may be used for patients at very high risk for life-threatening fungal or bacterial infections due to severe neutropenia; however, it is not recommended for all patients with MDS. Platelet transfusions should be avoided in patients with MDS who are not experiencing bleeding, regardless of platelet level. Iron chelation therapy should be considered in patients with a serum ferritin level greater than 1000 ng/mL or a history of receiving 20-25 units of packed red blood cells.

Learn more about MDS guidelines.


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