Fast Five Quiz: Anemia in Myelodysplastic Syndrome

Emmanuel C. Besa, MD

Disclosures

May 12, 2021

The classic bone marrow findings associated with MDS are red blood cell dysplasia with multinuclearity and ringed sideroblasts, which occur due to iron accumulation in mitochondria.

In MDS, peripheral blood smear results most often show red blood cell macrocytosis and macro-ovalocytes. Most patients with MDS have bone marrow hypercellularity. Hypocellularity is more characteristic of aplastic anemia. In MDS, red blood cells are plentiful but look abnormal. Absence of erythroblasts occurs in pure red blood cell aplasia or aplastic anemia.

Learn more about anemia in patients with MDS.

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