Fast Five Quiz: Heart Failure With Reduced Ejection Fraction (HFrEF)

Yasmine S. Ali, MD


June 10, 2021

Measurement of BNP supports a clinical diagnosis, and can help differentiate between cardiac and noncardiac causes of dyspnea in ambiguous cases. BNP appears to be released in direct proportion to ventricular volume and pressure overload. It is an independent predictor of high LV end-diastolic pressure and can be used to assess mortality risk in patients with HF. BNP and N-Terminal (NT)-proBNP may also be useful for monitoring guideline-directed medical therapy responses.

BNP is the strongest predictor of systolic versus nonsystolic HF; yet, it does not reliably differentiate between HFpEF and HFrEF.

BNP levels are higher in older patients, women, and patients with renal dysfunction or sepsis. They may be disproportionately lower in patients who are obese due to disorders of fat metabolism, or in patients with hypothyroidism or advanced end-stage HF.

Learn more about BNP and HF workup.


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