Fast Five Quiz: Hemophagocytic Lymphohistiocytosis

Sarah K. Tasian, MD


June 19, 2020

Various dermatologic manifestations may be observed in patients with HLH. Petechiae, purpura, or ecchymoses may occur as the result of thrombocytopenia. Pervasive systemic inflammation may result in erythematous maculopapular rashes or widespread erythroderma.

Patients with HLH frequently have a cluster of signs and symptoms that comprise some combination of organomegaly (lymphadenopathy, hepatomegaly, or splenomegaly), neurologic dysfunction (eg, encephalitis, seizures, or coma), fever, edema, and stigmata of liver dysfunction or coagulopathy (eg, jaundice or bruising), as well as dermatologic manifestations. Patients are often critically ill and quickly devolve toward a septic shock–like clinical picture that is associated with significant mortality if not recognized and treated promptly.

Learn more about the clinical presentation of HLH.


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