Fast Five Quiz: Sepsis Key Aspects

Richard H. Sinert, DO


June 17, 2020

The latest guidelines from the Surviving Sepsis Campaign give a detailed overview of initial resuscitation, screening, and diagnosis of sepsis. Management decisions on antibiotic therapy, fluid administration, source control, administration of pressors and steroids, blood products, anticoagulants, immunoglobulins, mechanical ventilation, sedation, analgesia, glucose control, blood purification, renal replacement therapy, bicarbonate, venous thromboembolism and stress ulcer prophylaxis, nutrition, and setting goals of care are also addressed.

Specific recommendations include the following:

  • The guidelines recommend daily assessment for de-escalation of antimicrobial therapy in patients with sepsis and septic shock to avoid unnecessarily prolonged use of those drugs.

  • The guidelines recommend against the use of sustained systemic antimicrobial prophylaxis in patients with severe inflammatory states of noninfectious origin.

  • The guidelines recommend against combination therapy using at least two antibiotics of different antimicrobial classes for the routine treatment of neutropenic sepsis/bacteremia.

  • In resuscitation from sepsis-induced hypoperfusion, at least 30 mL/kg of IV crystalloid fluid is recommended within the first 3 hours.

Read more about guidelines for sepsis.

This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases article Bacterial Sepsis.

Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

Follow Medscape on Facebook, Twitter, Instagram, and YouTube


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.