Fast Five Quiz: Psoriasis Comorbidities

William James, MD


December 17, 2021

Figure 1. Psoriatic arthritis of the foot.

PsA is the most well-recognized comorbidity of psoriasis. Nonetheless, approximately 20% of patients with psoriasis are believed to have undiagnosed PsA. Overall, prevalence estimates for PsA vary from 6% to 41% in patients with psoriasis, depending on the definitions used and populations studied. With the growing recognition of the Classification Criteria for Psoriatic Arthritis, it has been found that 1 in 4 patients with psoriasis have PsA, and more cases are expected to be reported.

PsA is a heterogeneous inflammatory arthritis; joint or entheseal inflammation and extra-articular manifestations are hallmark features. Although the prevalence of PsA increases with psoriasis severity, the severity of psoriasis is only weakly associated with the severity of joint disease.

Men and women are equally likely to develop PsA; however, women are more prone to experiencing more severe fatigue and work disability than men. In addition, gender differences exist in presentation and severity. For instance, men tend to experience axial involvement, whereas women tend to present with peripheral polyarticular disease.

Learn more about the manifestations of psoriasis.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.