Fast Five Quiz: Schizophrenia Management in Adults

Stephen Soreff, MD


August 11, 2020

First-generation antipsychotics have a high rate of extrapyramidal side effects, including rigidity, bradykinesia, dystonias, tremor, and akathisia. Tardive dyskinesia —involuntary movements of the face and extremities — is another adverse effect that can occur with first-generation antipsychotics. Patients find these muscle symptoms uncomfortable, and this often leads to nonadherence with medication.

Second-generation (novel or atypical) antipsychotics, with the exception of aripiprazole, are dopamine D2 antagonists but are associated with lower rates of extrapyramidal adverse effects and tardive dyskinesia than the first-generation antipsychotics. However, they have higher rates of metabolic adverse effects, including abnormalities in glucose and lipid control, and weight gain.

Learn more about schizophrenia medication.


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