Fast Five Quiz: Prognosis of Primary Myelofibrosis

Emmanuel C. Besa, MD


July 16, 2020

Figure 1. Enlarged spleen (splenomegaly). Light micrograph of a section through an enlarged spleen that has occurred in myelofibrosis.

PMF is an uncommon disease, with an annual incidence of approximately 0.5-1.5 cases per 100,000 individuals in the United States. In addition to White individuals, an increased prevalence rate of PMF has been noted in Ashkenazi Jews. In an epidemiologic study in 339 patients with myeloproliferative disorders in northern Israel, incidence of PMF was found to be 10- and 20-fold higher in Ashkenazi Jews than in Sephardic Jews and Arabs, respectively.

PMF can occur at any age; however, most cases are in individuals over 50 years, with the median age at diagnosis being ~65 years.

Learn more about the epidemiology of PMF.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.