Fast Five Quiz: Acute Infantile Spinal Muscular Atrophy Type 1, or Werdnig-Hoffmann Disease

Stephen L. Nelson, Jr, MD, PhD


August 12, 2020

In patients with SMA type 1, deep tendon reflexes are diminished or absent. Sphincteral abnormalities and long tract signs are also not seen.

Sensory examination findings are normal in patients with SMA type 1. Muscle weakness is greater in proximal muscles than in distal muscles; this muscle weakness may be reminiscent of myopathy.

Learn more about the clinical presentation of SMA.


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