Fast Five Quiz: Urothelial Carcinoma

Kyle A. Richards, MD


August 13, 2020

Among the 182,114 patients diagnosed with urothelial carcinoma in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2014, most patients were male (75.1%) and White (91.3%).

Urothelial carcinoma of the bladder is the fourth most common cancer among men and the 10th most common cancer among women in the United States. Even with optimal treatment, bladder cancer recurs in more than half of cases and may progress to muscle-invasive bladder cancer in up to 20% of these patients.

The most significant environmental factor associated with increased risk for urothelial carcinoma is cigarette smoking, being responsible for about 55% of all cases in the United States. Occupational exposure to carcinogens is correlated with 20% of cases, especially in industrial areas processing paint and dye. Obesity has also been shown to be a major risk factor contributing to urothelial carcinoma: A meta-analysis of 15 cohort studies including more than 38,000 patients with urothelial carcinoma showed a 4.2% increase in the incidence of bladder cancer for each 5-kg/m3 increase in body weight.

Learn more about the etiology of urothelial carcinoma.


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