Fast Five Quiz: Atopic Dermatitis Presentation and Diagnosis

William D. James, MD


September 14, 2020

Figure 1. Atopic dermatitis.

Atopic dermatitis is believed to result from a complex interplay between environmental exposures, epidermal barrier dysfunctions, and immune dysregulation. Although a single genetic risk factor has not been identified, mutations in filaggrin are thought to play a role in the pathogenesis of the disease. A deficiency in filaggrin weakens skin barrier integrity, resulting in increased epidermal permeability and susceptibility to irritant and allergic reactions.

A family history of allergic rhinitis, asthma, or atopic dermatitis increases the risk for atopic dermatitis. The disease is more prevalent in urban areas than in rural areas.

Passive tobacco smoke is considered a modest risk factor for the development of atopic dermatitis.

Learn more about atopic dermatitis.


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