Fast Five Quiz: Opioid-Induced Constipation

B.S. Anand, MD


October 15, 2020

Combination opioid agonist/antagonist agents are associated with a lower risk for constipation than are oral and parenteral morphine, whereas both oral and parenteral morphine preparations may induce more constipation than transdermal opioids.

Prucalopride is a highly selective 5-HT4 receptor agonist that has been shown to promote colonic motility without clinically significant cardiotoxicity.

The European Association for Palliative Care guidelines for opioid therapy in patients with cancer strongly recommend routine prescription of laxatives to prevent and manage opioid-induced constipation. Osmotic and stimulant laxatives are commonly prescribed.

Learn more about constipation associated with the use of opioids.


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