A lesion that hyperfluoresces in the early phases of the angiogram, maintains well-demarcated borders, and leaks late (obscuring its borders) is consistent with a classic CNV. A lesion with borders that cannot be determined by FA is an occult CNV.
Rapid-sequence FA is performed in many patients with the signs and symptoms of exudative AMD. Abnormalities are discovered in areas where the dye accumulates (hyperfluorescence) or is absent (hypofluorescence). FA findings consistent with exudative AMD include hypofluorescent blockage from subretinal hemorrhage; increasing hyperfluorescence secondary to dye leakage from the CNV may also be seen.
Other findings that are consistent with any form of AMD include hyperfluorescence of drusen and RPE atrophy as well as hypofluorescence from RPE hypertrophy.
Learn more about imaging studies in wet AMD.
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Cite this: F. Ryan Prall. Fast Five Quiz: Exudative (Wet) Age-Related Macular Degeneration Presentation and Diagnosis - Medscape - Feb 16, 2021.