Fast Five Quiz: Osteoporosis Hip Fracture Risk Factors

Herbert S. Diamond, MD


December 10, 2020

Antiparkinson drugs have been associated with increased relative and absolute risk for hip fracture. Negative postural adjustments and sway associated with these drugs may be responsible by predisposing patients to falls.

Studies have shown that the risk for hip fracture doubles with the use of antidepressants. Antidepressants may influence fall risk by decelerating cognitive or reflex reaction alertness.

Data from the Women's Health Initiative identified 11 clinical risk factors to predict 5-year hip fracture risk in White women. These are weight, height, age, race/ethnicity, self-reported health, physical activity, parental hip fracture, fracture history after age 54 years, current smoking, corticosteroid use, and history of treated diabetes.

A population-based cohort study found that diseases of the blood conferred an approximately threefold increased risk for hip fracture. Deficiency anemias in particular are commonly seen in patients with hip fracture. Anemia has already been associated with reduced physical performance and falls among elderly persons and community-dwelling seniors, which highlights the importance of assessing for and treating blood diseases among at-risk populations as a component of fracture prevention.

Learn more about the assessment of fracture risk and the management of osteoporosis.

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