Fast Five Quiz: Castration-Resistant Prostate Cancer

Kyle A. Richards, MD


December 02, 2020

Figure 1. Prostate cancer. A posterolateral view (left side) of the male reproductive organs is shown. The prostate possesses a tumor on its posterior wall.

A recent conceptual shift in the understanding of prostate cancer has brought about the understanding that castration resistance does not necessarily equal resistance to hormonal manipulations. Evidence shows that circulating intraprostatic androgen levels remain high despite the reduction of serum testosterone levels. This finding indicates the presence of certain functional adaptations that facilitate a continued response even with low levels of circulating androgens.

Some of these adaptations include AR gene mutations, AR splice variant expression, AR gene overexpression, increased expression of proteins acting as transcriptional coactivators, and upregulation of the enzymes involved in androgen synthesis.

Learn more about the pathogenesis of CRPC.


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